Jun 11, 2010 spitz nevus is an acquired melanocytic lesion, which generally develops in children and adolescents, although it is not rare in adults. Nevus spilus speckled lentiginous nevus, naevus sur. Considering the differential diagnoses being atypical spitz nevus versus spitzoid melanoma, fluorescent in situ hybridization fish was performed with a negative result. Dermoscopedia is the online resource for dermoscopy and is provided by the international dermoscopy society. This name is no longer used since melanoma is a type of skin cancer and. Revised british group dysplastic nevus syndrome score. The term melanoma is used because the clinical and histologic appearance is similar to melanoma. The final histopathologic diagnosis was spitz nevus in 6 19% cases, atypical spitz tumor in 22 cases 69%, and spitzoid melanoma in 4 cases 12%. The immunohistochemical profile of spitz nevi and conventional. The typical or classic lesion is a pink papule or nodule, which appears suddenly and grows rapidly for a few months. Two additional atypical pediatric spitz nevi were obtained from the pathology files of duke. A spitz nevus can look very much a like a serious kind of skin.
Objectiveto achieve a clinicopathologic classification of spitz nevi by comparing their clinical. Theoretically, a spitz nevus does not removing because it is a benign grown like other moles. A case of spitz nevus with multiple satellite lesions. Typically, a spitz nevus is a solitary pink papule but some can be heavily pigmented with a very black appearance. Aug 14, 2019 spitz nevus, spitz tumor, and spitzoid melanoma. Spitz nevus, or benign juvenile melanoma, is most common in children, but does appear in adults. Nevus spilus speckled lentiginous nevus, naevus sur naevus are you confident of the diagnosis. Bd, they appear as pink to red, welldemarcated, domeshaped papules that can be ulcerated. Spitz nevus are noncancerous skin lesions that tend to be domeshaped, red, reddishbrown or dark colored. A spitz nevus also known as epithelioid and spindlecell nevus, benign juvenile melanoma, and spitzs juvenile melanoma is a benign melanocytic nevus, with specific clinical. Abstract the blue nevus is an abnormal collection of functioning dermal melanocytes and melanin. Spitz nevi are melanocytic proliferations characterized by spindled andor. However, it may resemble a malignant melanoma clinically and microscopically, so spitz naevi are often excised as a precaution. Jan 15, 2019 spitzoid melanoma of skin may occur in a previously benign mole.
There are several types of epidermal nevus that are defined in part by the type of epidermal cell. Spitz nevus genetic and rare diseases information center. In the past, spitz nevi were called benign juvenile melanoma. We herein report an 11yearold girl who came to our clinic with a swelling on the genital area of 2 months duration. F, g, dense blueblack pigmentation is characteristic of the pigmented spindle cell nevus of reed, which some consider a variant of spitz. Clinical, histopathologic and genomic features of spitz. This paper reports a case of spitz nevus with multiple satellite lesions on the abdomen of a 19yearold korean woman. Reviewed and approved by a member of the dovemed editorial board first uploaded. Spitz nevus are rare, benign moles that closely resemble melanoma. A spitz naevus or spitz s nevus is an uncommon type of mole melanocytic naevus. Affected individuals have one or more nevi that vary in size. This page was last edited on 22 october 2018, at 15.
The name juvenile melanoma is generally no longer used as it is neither a melanoma, nor does it occur only in children. The tumor appears as a regularlyshaped papule or nodule. Patients should address specific medical concerns with their physicians. Spitzs nevus is an example of a melanocytic neoplasm with the most consistently pleomorphic cytology, yet spitzs nevus is a benign neoplasm. Spitz nevus is an acquired melanocytic lesion, which generally develops in children and adolescents, although it is not rare in adults. All structured data from the file and property namespaces is available under the creative commons cc0 license. Conversely, many examples of melanoma contain relatively small, monomorphous melanocytes. Started in 1995, this collection now contains 6767 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. Commonly it is localized on the head, back, hands and legs with size to 1 cm. Family practice notebook 2020, family practice notebook, llc. Spitz nevi are most often found in children but adults account for of all cases. The cases reported in the present study were retrieved from the pathology files of the university of graz in austria and of the.
A, classical spitz nevi most frequently occur on the face. Common terms, including mole, birthmark, and beauty mark, are used to describe nevi, but these terms do not distinguish specific. It is a group of nevus cells in the layers of the skin. Jun 02, 2011 spitz nevus are noncancerous skin lesions that tend to be domeshaped, red, reddishbrown or dark colored. Children and occasionally adults can develop a melanotic neoplasm called a spitz nevus, named for sophie spitz, a pathologist. It is classically believed to be benign, and conservatively. This is a pdf file of an unedited manuscript that has been. Nevus or nevi if multiple is a nonspecific medical term for a visible, circumscribed, chronic lesion of the skin or mucosa. It most often occurs on the face, scalp or legs of preadolescent children. Spitzoid melanoma of skin may occur in a previously benign mole. Spitz nevus is an infrequent, usually acquired melanocytic nevus composed of epithelioid andor spindle melanocytes that can occasionally be confused with melanoma. Dermatological examination of the patient was performed and a pigmented lesion was found on the inner surface of the labium majus of the mucosa. It was first described in 1948 but great controversy still remains today.
They usually develop on the face or limbs of young children. They are hairless, red to reddishpink, domeshaped papules or nodules with. Spitz naevus may pose great diagnostic difficulty due to clinical, dermatoscopic and histologic features resembling melanoma. Spitz nevus is a benign melnocytic lesion with many histologic similarities to malignant melanoma. Characteristic findings on physical examination a nevus spilus ns or speckled lentiginous nevus sln typically presents before the age of 2 as a light brown macule or patch containing smaller, more darkly pigmented macules or papules within the borders figure 1. Currently, there are no immunohistochemical markers or molecular biology techniques that can be used to make an entirely safe diagnosis of spitz nevus or melanoma in problematic cases. Spitz nevus photos click on tab labeled spitz nevus. These lesions are termed atypical spitz nevitumors and there is. Although access to this page is not restricted, the information found here is intended for use by medical providers. Epidermal nevi are typically seen at birth or develop in early childhood. Followup information of the patients was unavailable. Whats more, these nevi are not always easily distinguished from melanoma even by expert dermatopathologists. Jul 26, 2017 a spitz nevus is a rare type of skin mole that usually affects young people and children.
The intradermal pattern displays maturation, with singlefile or singleunit arrays. However, it is often difficult for a clinician to be certain that the condition is a spitz nevus. Clinicalgreyblue sometimes black colored patch or papula. Pdf spitz and reed nevi, also called spindle andor epithelioid cell nevi, are. Becker nevus syndrome is a phenotype characterized by the fundamental presence of beckers nevus with ipsilateral hypoplasia of the breast or other skin, skeletal. This lesion is typically a rapidly growing pink nodule, but the lesion can sometimes be pigmented. Nevus in spanish, translation, englishspanish dictionary. Spitz nevus, acral nevus, acral lentiginous melanoma, immunohistochemistry, p16, p21. Although it can look like a serious form of skin cancer called melanoma, a spitz nevus lesion isnt. The lesion was well circumscribed and approximately 1 cm in diameter, with homogenous color distribution. Files are available under licenses specified on their description page. A retrospective study has been carried out that included all the cases diagnosed as spitz nevus from our files.
A 1cm raised red domeshaped nodule that suddenly appeared on the shoulder of a child. It also may be called a nevus, spitz lesion, juvenile melanoma, benign juvenile melanoma, or spindle and epithelioid cell nevus of reed. The intradermal pattern displays maturation, with singlefile or single unit arrays. Oct 09, 2014 spitz nevus are rare, benign moles that closely resemble melanoma. A type of melanocytic nevus, it affects the epidermis and dermis it is also known as an epithelioid and spindlecell nevus, and misleadingly as a benign juvenile melanoma. A spitz naevus or spitzs nevus is an uncommon type of mole melanocytic naevus. Though usually seen in children, spitz naevi may arise in adults. Occasionally, spitz nevi arise in clusters of multiple lesions called agminated spitz nevi. They tend to grow quickly initially, but then stabilize or even disappear after a period of time. Pdf a conjunctival spitz nevus is a very rare, benign melanocytic lesion, which can be mistaken for a.
Spitzoid melanomas were distinguished from atypical spitz tumors by histopathologic features including increased nuclear pleomorphism, the presence of epidermal consumption, lack of maturation. To our knowledge, a spitz nevus with multiple satellite lesions has not been reported. Spitz nevus of the genital mucosa tspace repository. The spitz nevus is a benign melanocytic lesion with clinical and histopathological features similar to those of melanoma.
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